Journal article
Cellular Interactions of Liposomes and PISA Nanoparticles during Human Blood Flow in a Microvascular Network
MN Vu, HG Kelly, AK Wheatley, S Peng, EH Pilkington, NA Veldhuis, TP Davis, SJ Kent, NP Truong
Small | WILEY-V C H VERLAG GMBH | Published : 2020
Abstract
A key concept in nanomedicine is encapsulating therapeutic or diagnostic agents inside nanoparticles to prolong blood circulation time and to enhance interactions with targeted cells. During circulation and depending on the selected application (e.g., cancer drug delivery or immune modulators), nanoparticles are required to possess low or high interactions with cells in human blood and blood vessels to minimize side effects or maximize delivery efficiency. However, analysis of cellular interactions in blood vessels is challenging and is not yet realized due to the diverse components of human blood and hemodynamic flow in blood vessels. Here, the first comprehensive method to analyze cellular..
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Grants
Awarded by Australian Research Council
Funding Acknowledgements
N.P.T., S.J.K., and T.P.D. acknowledge the receipt of a Discovery Project grant (DP200100231) from the Australian Research Council (ARC). N.P.T. is grateful for the award of a DECRA Fellowship from the ARC (DE180100076). This work was carried out within the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036). The authors would like to thank Prof. Athina Anastasaki (ETH Zurich) for useful scientific discussions, Dr. Simon Crawford (Monash University) for assistance with Cryo-TEM, and Ms. Vinca Alcantara (University of Melbourne) for technical support on blood assays. M.N.V. acknowledges the financial support from Monash Graduate Scholarship (MGS) and Monash International Postgraduate Research Scholarship (MIPRS).